Normalization of a NAFLD gene expression signature
نویسندگان
چکیده
منابع مشابه
Gene expression in human NAFLD.
Despite the high prevalence of nonalcoholic fatty liver disease (NAFLD), little is known of its pathogenesis based on study of human liver samples. By the use of Affymetrix GeneChips (17,601 genes), we investigated gene expression in the human liver of subjects with extreme steatosis due to NAFLD without histological signs of inflammation (liver fat 66.0 +/- 6.8%) and in subjects with low liver...
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Array-based gene expression studies frequently serve to identify genes that are expressed differently under two or more conditions. The actual analysis of the data, however, may be hampered by a number of technical and statistical problems. Possible remedies on the level of computational analysis lie in appropriate preprocessing steps, proper normalization of the data and application of statist...
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Advances in microarray technologies have made it possible to comprehensively measure gene expression profiles. However, in these experiments, the efficiency of fluorescent dyes are different between different experiments, and adjustments of these expression values are mandatory before the analysis, It is referred to as normalization. Although the most popular method is total intensity normaliza...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2014
ISSN: 0270-9139
DOI: 10.1002/hep.27042